Meeting Program

Imaging and Characterizing Structure and Function in Native and Engineered Tissue

Thursday, January 17

4:00 - 8:00 p.m. 

Registration, Lower Level Registration Desk

Friday, January 18
6:30 - 7:30 a.m. 
Poster setup, Salons G & H
7:00 - 8:00 a.m. 
Continental Breakfast & Registration, Salon F
7:30 - 8:00 a.m. 
Moderators’ Meeting, Salon G
8:00 - 8:30 a.m. 
Welcoming Remarks
8:30 - 10:00 a.m. 
Heterogeneous Single Cell Measurements and Their Integration into Tissue and Organism Models
10:00 - 10:15 a.m. 
Break and Poster Viewing
10:15 a.m. - 11:45 a.m. 
Functional, Molecular and Structural Imaging of Engineered Tissue in vitro and in vivo
11:45 a.m. - 1:00 p.m. 
Lunch & Poster Viewing (Lunch in Salon F)
1:00 - 2:30 p.m. 
New Technologies for Characterizing Cells and Tissues in situ
2:30 - 3:00 p.m. 
Break and Poster Viewing
3:00 - 4:30 p.m. 
Imaging for Targeted Cell, Gene and Drug Delivery
4:30 - 6:30 p.m. 
Breakout Sessions I-IV, Salons G-H
6:45 - 8:00 p.m. 

Dinner, Salon F

Saturday, January 19, 2008

7:00 - 8:00 a.m. 
Continental Breakfast, Salon F
8:00 - 10:30 a.m. 
Breakout Reports and Discussion, Salons G-H
10:30 - 11:15 a.m. 
General Discussion and Q & A
11:15 - 11:45 a.m. 
Final Remarks & Wrap-Up
12 - 12:30 p.m. 
Poster Tear Down


Plenary Session I: 
Heterogeneous Single Cell Measurements and Their Integrationn into Tissue and Organism Models

Moderators:  Robert Murphy, PhD and Warren Grundfest, MD/PhD

Polychromatic and Hyperspectral Flow Cytometry for Modeling Relationships in Heterogeneous Cell Populations - Dr. J. Paul Robinson, Purdue University, West Lafayette, IN

Automated Learning of Protein Subcellular Locations for Modeling of Cell Behavior - Dr. Robert F. Murphy, Carnegie Mellon University, Pittsburgh, PA

Optical Measurements and Light Distribution for the Detection of Cancer - Dr. Eva Sevick Muraca, Baylor College of Medicine, Houston, TX

Cellular and Tissue Optical Measurements for the Detection of Colo-Rectal Cancer -- Does the Field Effect Exist? - Dr. Vadim Backman, Northwestern University, Evanston, IL

Plenary Session II:

Functional Molecular and Structural Imaging of Engineered Tissue in vitro and in vivo

Moderators:  Anne Meyer, PhD and Christine Kelley, PhD

The Needs for Functional Imaging of Engineered tissues, in vitro and in
vivo - Dr. Gordana Vunjak-Novakovic

Multi-modality imaging of engineered tissues in vivo - Dr. Charles Lin, Massachusetts General Hospital, Boston, MA

Imaging for Design and Evaluation of Tissue Engineered Constructs - Dr. Scott Hollister, University of Michigan, Ann Arbor, MI

Optical Imaging of Engineered Tissues - Dr. Mark Brezinski, Brigham and Women's Hospital, Boston, MA

Plenary Session III: 
New Technologies for Characterizing Cells and Tissues in situ

Moderators:  Kevin Cleary, PhD, and Richard Ehman, MD

Energy Transduction Imaging:  PAT, TAT, UOT - Dr. L. Wang, Washington University at St. Louis, St. Louis, MO

New Technologies in Acoustical Tissue Characterization - Dr. Kathryn Nightingale, Duke University, Durham, NC

Magnetic Resonance Elastography - Dr. Richard Ehman, Mayo Clinic, Rochester, MN

Minimally Invasive Contact Tissue Characterization:  Sensors and Optical Imaging - Dr. Kevin Cleary, Georgetown Medical Center,Washington, DC

Plenary Session IV: 
Imaging for Targeted Cell, Gene and Drug Delivery

Moderators:  Vladimir Torchlin, PhD and William Phillips, MD

Dynamic imaging of targeted and activatable vehicles - Dr. Katherine Ferrara, University of California Davis, Sacramento, CA

Imaging of siRNA Delivery and Silencing - Dr. Anna V. Moore, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA

Liposomal Carriers for Drug Delivery Imaging - Dr. William Phillips, University of Texas Medical Center, San Antonio, TX

Imaging Component of Multifunctional Pharmaceutical Nanocarriers - Dr. Vladimir Torchlin, Northeastern University, Boston, MA

Plenary Session Abstracts:


Plenary Session I: 
Heterogeneous Single Cell Measurements and Their Integrationn into Tissue and Organism Models

Many technologies for assessing organisms in vivo, such as conventional imaging methods, provide information that is aggregated over a volume of tissue, averaging the behavior of a very large number of cells. New technologies are providing unprecedented abilities to target and probe the detailed functions of individual cells in vivo. This presents a new type of challenge, in connecting such information to the function and health of the organism as a whole. This session will focus on various approaches to this challenge.

Plenary Session II:

Functional Molecular and Structural Imaging of Engineered Tissue in vitro and in vivo

The goal of this session is to identify imaging needs and methods for non-invasive, fast, and accurate assessment of cell growth, differentiation, and tissue development, including matrix development, in engineered tissues. The talks will cover two main topics: (1) Molecular imaging in vivo, including non-invasive tracking and assessment of the fate of implanted cells and 3-dimensional (3D) engineered constructs; and (2) Structural and functional imaging of 3D engineered tissue constructs in vitro. These topics will encompass broad range of imaging modalities such as magnetic resonance imaging, micro PET, optical coherence tomography, multi-photon microscopy, as well as multi-modality imaging methods. The talks and discussion will be designed to facilitate interaction between researchers in the field of tissue engineering and those in the various imaging fields that could benefit tissue engineering. The challenges and opportunities for applying advances in imaging technologies to tissue engineering to advance the field of regenerative medicine will be discussed.

Plenary Session III: 
New Technologies for Characterizing Cells and Tissues in situ

Emerging technologies are offering new approaches for quantitatively assessing tissue properties that previously could not be measured in situ. Some of these opportunities involve novel imaging technologies that exploit interactions of energy with tissue and in some cases the conversion of one form of energy to another ("energy transduction") to provide new parameters for tissue characterization. Other approaches involve bringing sensors and microscopic imaging modalities into contact with tissues of interest by minimally-invasive, image guided techniques. Many of these technologies have as much relevance to the evaluation of engineered tissue constructs as they do for in vivo imaging. This session will have four speakers who will each provide a survey of specific emerging technologies, opportunities and unsolved problems.

Plenary Session IV: 
Imaging for Targeted Cell, Gene and Drug Delivery

The main goal of this session will be to present the data regarding the cutting edge research on the border between drug delivery and imaging areas. We will concentrate on very recent and new topics, which currently attract a lot of attention, such as cell-penetrating peptides, siRNA and gene silencing, image-guided drug delivery, acoustic delivery and imaging, etc. Depending on the final choice of the speakers, we may ask them to concentrate more on certain areas so that the whole program remains consistent.